How much would you pay for natural headache relief?? There is scientific proof the ingredients in this creme work as well as Tylenol, only faster. See renowned Keck School of Medicine of the University of Southern California. Rubbed on the forehead, temples and back of neck, you will feel an intensely hot sensation, then cool. Ahhh. Headache relief - fast! Do not use if on blood thinning medication, or, allergic to aspirin. External use only. Avoid eyes and mucous membranes.